916+ Vacation Rentals & Holiday Homes in Matlacha Isles |
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Matlacha Isles Accommodations - Hotels & Rentals

About Matlacha Isles Vacation Rentals

Discover More than 916 Incredible Getaway Rentals Available in Matlacha Isles. Choose from a Wide Selection of Villas, Hotels, and Other Rental Options. Explore Luxury Amenities at Affordable Prices, Creating the Ideal Base for Your Next Vacation. Plan Your Perfect Escape with Online Reservations and Uncover Fantastic Stays in Matlacha Isles.

Online Reservations Offers Numerous Last-Minute Deals on Villas, Hotels, and Rentals, Both Near You and Across the Globe. Whether You Need Accommodation for a Group or an Event, Be it a Hotel or Vacation Rental (Including Cabins and Private Luxury Villas), We're Here to Assist. With Online Reservations in Matlacha Isles, You Can Easily Compare Options from Multiple Suppliers with a Single Click to Find the Perfect Price Point, Amenities, and Style of Stay That Suit Your Needs. Looking for Group Deals, Properties with Private Pools, Hot Tubs, Pet-Friendly Options, or Spacious Master Suite Bedrooms with Open-Air Showers? You Can Find It All in the Online Reservations Vacation Rentals, Resorts, and Airbnb-Style Properties in Matlacha Isles. The Average Size of Places to Stay Near Matlacha Isles is 1424.26 ft², with Prices Averaging US $271 per Night.

Let Online Reservations Help You Discover the Ideal Holiday Rental to Create Lifelong Travel Memories in Matlacha Isles. Our Listed Prices Are Often Discounted Compared to Rack Rates. Simply Search for Your Destination and Secure the Perfect Place to Stay Today.

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Top Hotels & Vacation Rentals in Matlacha Isles

Type Count
Vacation Homes 694
Villas 130
Holiday Apartments 55
Cottages 10

Use these Quick Filters to Find a Vacation Rental in Matlacha Isles

★ Pro Tip: Online Reservations is a vacation rental website specializing in cottages, lake houses, and exclusive summer home rentals. We curate a vast selection of incredible properties from trusted suppliers, allowing you to compare prices and locations to find the perfect fit for your getaway. Create lasting memories in Matlacha Isles with Online Reservations.

Weather in Matlacha Isles, FL

View the weather forecast for Matlacha Isles before booking your Matlacha Isles Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Frequently Asked Questions About Matlacha Isles?

What are the top hotels, lake houses & vacation rentals in Matlacha Isles?

We provide an array of great vacation destinations in Matlacha Isles. If you are looking to stay in or around the Matlacha Isles area, make sure to browse our options to find a premium rental location in a top vacation destination. Whether it is a few nights, a week, or more, we've got the luxury stays that rank among the Top Vacation Rentals in Matlacha Isles:

How many Hotels & Vacation Rentals have private pools in Matlacha Isles?

We have 462 Hotels & Vacation Rentals featuring a private pool in and near Matlacha Isles. Some of the best destinations to stay that feature or have access to a swimming pool are:

Which hotel, lake house, or vacation rental in Matlacha Isles is best for families?

Searching for a family-friendly getaway in Matlacha Isles? We've got you covered. Check out one of these luxurious getaways that are highly-rated and perfect fits for families of all sizes.

How many hotels, resorts, or rentals are available in Matlacha Isles?

Online Reservations™ offers a consistent supply of new options, combined with established great stays in top areas. Currently, the number of properties listed by Online Reservations™ in 2025 is over 916 in the Matlacha Isles area, and that number rises every day. By combining listings from multiple websites and travel providers, Online Reservations™ can provide you with a diverse amount of choices of the best luxury stays in Matlacha Isles.

Nearby Neighborhood (1) 
Neighborhood Property Count
Burnt Store Vacation Rentals in Fort Myers, Florida 350

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