202+ Vacation Rentals & Holiday Homes in South Main |
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South Main Accommodations - Hotels & Rentals

About South Main Vacation Rentals

Discover More than 202 Incredible Getaway Rentals Available in South Main. Choose from a Wide Selection of Villas, Hotels, and Other Rental Options. Explore Luxury Amenities at Affordable Prices, Creating the Ideal Base for Your Next Vacation. Plan Your Perfect Escape with Online Reservations and Uncover Fantastic Stays in South Main.

Online Reservations Offers Numerous Last-Minute Deals on Villas, Hotels, and Rentals, Both Near You and Across the Globe. Whether You Need Accommodation for a Group or an Event, Be it a Hotel or Vacation Rental (Including Cabins and Private Luxury Villas), We're Here to Assist. With Online Reservations in South Main, You Can Easily Compare Options from Multiple Suppliers with a Single Click to Find the Perfect Price Point, Amenities, and Style of Stay That Suit Your Needs. Looking for Group Deals, Properties with Private Pools, Hot Tubs, Pet-Friendly Options, or Spacious Master Suite Bedrooms with Open-Air Showers? You Can Find It All in the Online Reservations Vacation Rentals, Resorts, and Airbnb-Style Properties in South Main. The Average Size of Places to Stay Near South Main is 459.4 ft², with Prices Averaging US $151 per Night.

Let Online Reservations Help You Discover the Ideal Holiday Rental to Create Lifelong Travel Memories in South Main. Our Listed Prices Are Often Discounted Compared to Rack Rates. Simply Search for Your Destination and Secure the Perfect Place to Stay Today.

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Top Hotels & Vacation Rentals in South Main

Type Count
Holiday Apartments 133
Vacation Homes 34

Use these Quick Filters to Find a Vacation Rental in South Main

★ Pro Tip: Online Reservations is a vacation rental website specializing in cottages, lake houses, and exclusive summer home rentals. We curate a vast selection of incredible properties from trusted suppliers, allowing you to compare prices and locations to find the perfect fit for your getaway. Create lasting memories in South Main with Online Reservations.

Weather in South Main, TX

View the weather forecast for South Main before booking your South Main Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Activities South MainGuest Reviews Local Attractions

A Large Selection of Hotels and Vacation Rentals from Around the World South MainGuest Reviews Discover Exciting Activities and Must-Visit Destinations for Your Upcoming Journey


Toyota Center
MD Anderson Cancer Center
NRG Stadium
Minute Maid Park
George R. Brown Convention Center
Houston Zoo
NRG Park
University of Houston
CityCentre
Downtown Aquarium
Rice University
Houston Museum District
Houston Natural Science Museum
Discovery Green
Memorial City Mall
Smart FiNonecial Centre at Sugar Land
Children's Museum of Houston
House of Blues Houston
Memorial Park
Revention Music Center

Frequently Asked Questions About South Main?

What are the top hotels, lake houses & vacation rentals in South Main?

We provide an array of great vacation destinations in South Main. If you are looking to stay in or around the South Main area, make sure to browse our options to find a premium rental location in a top vacation destination. Whether it is a few nights, a week, or more, we've got the luxury stays that rank among the Top Vacation Rentals in South Main:

How many Hotels & Vacation Rentals have private pools in South Main?

We have 11 Hotels & Vacation Rentals featuring a private pool in and near South Main. Some of the best destinations to stay that feature or have access to a swimming pool are:

Which hotel, lake house, or vacation rental in South Main is best for families?

Searching for a family-friendly getaway in South Main? We've got you covered. Check out one of these luxurious getaways that are highly-rated and perfect fits for families of all sizes.

How many hotels, resorts, or rentals are available in South Main?

Online Reservations™ offers a consistent supply of new options, combined with established great stays in top areas. Currently, the number of properties listed by Online Reservations™ in 2025 is over 202 in the South Main area, and that number rises every day. By combining listings from multiple websites and travel providers, Online Reservations™ can provide you with a diverse amount of choices of the best luxury stays in South Main.

Nearby Neighborhood (2) 
Neighborhood Property Count
Texas Medical Center Vacation Rentals in Houston, Texas 442
Astrodome Vacation Rentals in Houston, Texas 241

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