103+ Vacation Rentals & Holiday Homes in Clayton |
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Clayton Accommodations - Hotels & Rentals

About Clayton Vacation Rentals

Discover More than 103 Incredible Getaway Rentals Available in Clayton. Choose from a Wide Selection of Villas, Hotels, and Other Rental Options. Explore Luxury Amenities at Affordable Prices, Creating the Ideal Base for Your Next Vacation. Plan Your Perfect Escape with Online Reservations and Uncover Fantastic Stays in Clayton.

Online Reservations Offers Numerous Last-Minute Deals on Villas, Hotels, and Rentals, Both Near You and Across the Globe. Whether You Need Accommodation for a Group or an Event, Be it a Hotel or Vacation Rental (Including Cabins and Private Luxury Villas), We're Here to Assist. With Online Reservations in Clayton, You Can Easily Compare Options from Multiple Suppliers with a Single Click to Find the Perfect Price Point, Amenities, and Style of Stay That Suit Your Needs. Looking for Group Deals, Properties with Private Pools, Hot Tubs, Pet-Friendly Options, or Spacious Master Suite Bedrooms with Open-Air Showers? You Can Find It All in the Online Reservations Vacation Rentals, Resorts, and Airbnb-Style Properties in Clayton. The Average Size of Places to Stay Near Clayton is 336.8 ft², with Prices Averaging US $189 per Night.

Let Online Reservations Help You Discover the Ideal Holiday Rental to Create Lifelong Travel Memories in Clayton. Our Listed Prices Are Often Discounted Compared to Rack Rates. Simply Search for Your Destination and Secure the Perfect Place to Stay Today.

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Top Hotels & Vacation Rentals in Clayton

Type Count
Vacation Homes 39
Holiday Apartments 32
Cottages 1
Villas 1

Use these Quick Filters to Find a Vacation Rental in Clayton

★ Pro Tip: Online Reservations is a vacation rental website specializing in cottages, lake houses, and exclusive summer home rentals. We curate a vast selection of incredible properties from trusted suppliers, allowing you to compare prices and locations to find the perfect fit for your getaway. Create lasting memories in Clayton with Online Reservations.

Weather in Clayton, MO

View the weather forecast for Clayton before booking your Clayton Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Activities ClaytonGuest Reviews Local Attractions

A Large Selection of Hotels and Vacation Rentals from Around the World ClaytonGuest Reviews Discover Exciting Activities and Must-Visit Destinations for Your Upcoming Journey


Plaza Clayton
Chapel of St. Timothy And St. Titus
St. Louis Union Station
Gateway Arch
City Museum
Forest Park
Busch Stadium
St. Louis Zoo
Enterprise Center
Washington University
Six Flags St. Louis
Westport Plaza
Fox Theater
Hollywood Casino Amphitheatre
Ameristar Casino St. Charles
Dome at Americas Center
Chaifetz Arena
St. Louis University
Barnes Jewish Hospital
America's Center Convention Complex

Find Hotels & Vacation Rentals in these Cities and Neighborhoods


Demun 1,002 Properties
Chapel of St. Timothy And St. Titus 958 Properties
Moorlands 517 Properties
Plaza Clayton 481 Properties
Downtown 357 Properties
North Clayton 280 Properties
Ladue 146 Properties

Frequently Asked Questions About Clayton?

What are the top hotels, lake houses & vacation rentals in Clayton?

We provide an array of great vacation destinations in Clayton. If you are looking to stay in or around the Clayton area, make sure to browse our options to find a premium rental location in a top vacation destination. Whether it is a few nights, a week, or more, we've got the luxury stays that rank among the Top Vacation Rentals in Clayton:

How many Hotels & Vacation Rentals have private pools in Clayton?

We have 1 Hotels & Vacation Rentals featuring a private pool in and near Clayton. Some of the best destinations to stay that feature or have access to a swimming pool are:

Which hotel, lake house, or vacation rental in Clayton is best for families?

Searching for a family-friendly getaway in Clayton? We've got you covered. Check out one of these luxurious getaways that are highly-rated and perfect fits for families of all sizes.

How many hotels, resorts, or rentals are available in Clayton?

Online Reservations™ offers a consistent supply of new options, combined with established great stays in top areas. Currently, the number of properties listed by Online Reservations™ in 2025 is over 103 in the Clayton area, and that number rises every day. By combining listings from multiple websites and travel providers, Online Reservations™ can provide you with a diverse amount of choices of the best luxury stays in Clayton.

Nearby Neighborhood (5) 
Neighborhood Property Count
Downtown Vacation Rentals in St. Louis, Missouri 357
North Clayton Vacation Rentals in St. Louis, Missouri 280
Wydown Skinker Vacation Rentals in St. Louis, Missouri 1234
Demun Vacation Rentals in St. Louis, Missouri 1002
Moorlands Vacation Rentals in St. Louis, Missouri 517

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