1486+ Vacation Rentals & Holiday Homes in Isle of Palms South |
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  3. Jacksonville
  4. Isle of Palms South

Isle of Palms South Accommodations - Hotels & Rentals

About Isle of Palms South Vacation Rentals

Discover More than 1486 Incredible Getaway Rentals Available in Isle of Palms South. Choose from a Wide Selection of Villas, Hotels, and Other Rental Options. Explore Luxury Amenities at Affordable Prices, Creating the Ideal Base for Your Next Vacation. Plan Your Perfect Escape with Online Reservations and Uncover Fantastic Stays in Isle of Palms South.

Online Reservations Offers Numerous Last-Minute Deals on Villas, Hotels, and Rentals, Both Near You and Across the Globe. Whether You Need Accommodation for a Group or an Event, Be it a Hotel or Vacation Rental (Including Cabins and Private Luxury Villas), We're Here to Assist. With Online Reservations in Isle of Palms South, You Can Easily Compare Options from Multiple Suppliers with a Single Click to Find the Perfect Price Point, Amenities, and Style of Stay That Suit Your Needs. Looking for Group Deals, Properties with Private Pools, Hot Tubs, Pet-Friendly Options, or Spacious Master Suite Bedrooms with Open-Air Showers? You Can Find It All in the Online Reservations Vacation Rentals, Resorts, and Airbnb-Style Properties in Isle of Palms South. The Average Size of Places to Stay Near Isle of Palms South is 790.2 ft², with Prices Averaging $384 per Night.

Let Online Reservations Help You Discover the Ideal Holiday Rental to Create Lifelong Travel Memories in Isle of Palms South. Our Listed Prices Are Often Discounted Compared to Rack Rates. Simply Search for Your Destination and Secure the Perfect Place to Stay Today.

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Top Hotels & Vacation Rentals in Isle of Palms South

Type Count
Vacation Homes 1030
Holiday Apartments 254
Cottages 15
Villas 10

Use these Quick Filters to Find a Vacation Rental in Isle of Palms South

★ Pro Tip: Online Reservations is a vacation rental website specializing in cottages, lake houses, and exclusive summer home rentals. We curate a vast selection of incredible properties from trusted suppliers, allowing you to compare prices and locations to find the perfect fit for your getaway. Create lasting memories in Isle of Palms South with Online Reservations.

Weather in Isle of Palms South, FL

View the weather forecast for Isle of Palms South before booking your Isle of Palms South Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Activities Isle of Palms SouthGuest Reviews Local Attractions

A Large Selection of Hotels and Vacation Rentals from Around the World Isle of Palms SouthGuest Reviews Discover Exciting Activities and Must-Visit Destinations for Your Upcoming Journey


Jacksonville Cruise Terminal
Mayo Clinic Florida
St. Johns Town Center
Jacksonville Naval Air Station
TPC Sawgrass
VyStar Veterans Memorial Arena
TIAA Bank Field
Jacksonville Zoo and Gardens
Mayport Naval Station
University of North Florida
Jacksonville University
Daily's Place
Memorial Hospital Jacksonville
Jacksonville Beach Pier
Florida Theatre
bestbet Orange Park
Adventure Landing
Cummer Museum of Art and Gardens
Prime F. Osborn Convention Center
Metropolitan Park

Frequently Asked Questions About Isle of Palms South?

What are the top hotels, lake houses & vacation rentals in Isle of Palms South?

We provide an array of great vacation destinations in Isle of Palms South. If you are looking to stay in or around the Isle of Palms South area, make sure to browse our options to find a premium rental location in a top vacation destination. Whether it is a few nights, a week, or more, we've got the luxury stays that rank among the Top Vacation Rentals in Isle of Palms South:

How many Hotels & Vacation Rentals have private pools in Isle of Palms South?

We have 126 Hotels & Vacation Rentals featuring a private pool in and near Isle of Palms South. Some of the best destinations to stay that feature or have access to a swimming pool are:

Which hotel, lake house, or vacation rental in Isle of Palms South is best for families?

Searching for a family-friendly getaway in Isle of Palms South? We've got you covered. Check out one of these luxurious getaways that are highly-rated and perfect fits for families of all sizes.

How many hotels, resorts, or rentals are available in Isle of Palms South?

Online Reservations™ offers a consistent supply of new options, combined with established great stays in top areas. Currently, the number of properties listed by Online Reservations™ in 2025 is over 1486 in the Isle of Palms South area, and that number rises every day. By combining listings from multiple websites and travel providers, Online Reservations™ can provide you with a diverse amount of choices of the best luxury stays in Isle of Palms South.

Nearby Neighborhood (2) 
Neighborhood Property Count
Southside Vacation Rentals in Jacksonville, Florida 730
Isle of Palms Vacation Rentals in Jacksonville, Florida 35

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