178+ Vacation Rentals & Holiday Homes in Eastern Panama |
  1. Panama
  2. Eastern Panama

Eastern Panama Accommodations - Hotels & Rentals

About Eastern Panama Vacation Rentals

Discover More than 178 Incredible Getaway Rentals Available in Eastern Panama. Choose from a Wide Selection of Villas, Hotels, and Other Rental Options. Explore Luxury Amenities at Affordable Prices, Creating the Ideal Base for Your Next Vacation. Plan Your Perfect Escape with Online Reservations and Uncover Fantastic Stays in Eastern Panama.

Online Reservations Offers Numerous Last-Minute Deals on Villas, Hotels, and Rentals, Both Near You and Across the Globe. Whether You Need Accommodation for a Group or an Event, Be it a Hotel or Vacation Rental (Including Cabins and Private Luxury Villas), We're Here to Assist. With Online Reservations in Eastern Panama, You Can Easily Compare Options from Multiple Suppliers with a Single Click to Find the Perfect Price Point, Amenities, and Style of Stay That Suit Your Needs. Looking for Group Deals, Properties with Private Pools, Hot Tubs, Pet-Friendly Options, or Spacious Master Suite Bedrooms with Open-Air Showers? You Can Find It All in the Online Reservations Vacation Rentals, Resorts, and Airbnb-Style Properties in Eastern Panama. The Average Size of Places to Stay Near Eastern Panama is 298.64 ft², with Prices Averaging US $406 per Night.

Let Online Reservations Help You Discover the Ideal Holiday Rental to Create Lifelong Travel Memories in Eastern Panama. Our Listed Prices Are Often Discounted Compared to Rack Rates. Simply Search for Your Destination and Secure the Perfect Place to Stay Today.

Show more
Show less

Top Hotels & Vacation Rentals in Eastern Panama

Type Count
Vacation Homes 37
Holiday Apartments 13
Cottages 4
Villas 4

Use these Quick Filters to Find a Vacation Rental in Eastern Panama

★ Pro Tip: Online Reservations is a vacation rental website specializing in cottages, lake houses, and exclusive summer home rentals. We curate a vast selection of incredible properties from trusted suppliers, allowing you to compare prices and locations to find the perfect fit for your getaway. Create lasting memories in Eastern Panama with Online Reservations.

Weather in Eastern Panama, PA

View the weather forecast for Eastern Panama before booking your Eastern Panama Vacation Rentals to confirm your best time to go.

December - February
High 91°F       Low 70°F
March - May
High 92°F       Low 71°F
June - August
High 91°F       Low 72°F
September - November
High 87°F       Low 73°F

Activities Eastern PanamaGuest Reviews Local Attractions

A Large Selection of Hotels and Vacation Rentals from Around the World Eastern PanamaGuest Reviews Discover Exciting Activities and Must-Visit Destinations for Your Upcoming Journey


Isla Mamey
Cayos Holandeses
Portobelo National Park
Porvenir Museum
Museum
Museum of the Kuna Nation
Colon Free Zone
Blanca Beach
Soberania National Park
Darien National Park
Chagres National Park
Galeta Island Marine Education Center
Area Silvestre de Nargana
Chepo Youth Recreation Center
Mirador Peru
Safarick's Zoo
Chepo Regional Hospital
Fuerte San FerNonedo
Gatun Eco Adventures
Fuerte Santiago

Find Hotels & Vacation Rentals in these Cities and Neighborhoods


Guna Yala 131 Properties
Carti Tupile 94 Properties
Carti 92 Properties
Portobelo National Park 56 Properties
El Porvenir 55 Properties
Achutupo 55 Properties
Cacique 51 Properties
Palenque 46 Properties
Nombre de Dios 46 Properties
Puerto Lindo 33 Properties
Isla Grande 24 Properties
Nusatupo 24 Properties

Frequently Asked Questions About Eastern Panama?

What are the top hotels, lake houses & vacation rentals in Eastern Panama?

We provide an array of great vacation destinations in Eastern Panama. If you are looking to stay in or around the Eastern Panama area, make sure to browse our options to find a premium rental location in a top vacation destination. Whether it is a few nights, a week, or more, we've got the luxury stays that rank among the Top Vacation Rentals in Eastern Panama:

How many Hotels & Vacation Rentals have private pools in Eastern Panama?

We have 1 Hotels & Vacation Rentals featuring a private pool in and near Eastern Panama. Some of the best destinations to stay that feature or have access to a swimming pool are:

Which hotel, lake house, or vacation rental in Eastern Panama is best for families?

Searching for a family-friendly getaway in Eastern Panama? We've got you covered. Check out one of these luxurious getaways that are highly-rated and perfect fits for families of all sizes.

How many hotels, resorts, or rentals are available in Eastern Panama?

Online Reservations™ offers a consistent supply of new options, combined with established great stays in top areas. Currently, the number of properties listed by Online Reservations™ in 2025 is over 178 in the Eastern Panama area, and that number rises every day. By combining listings from multiple websites and travel providers, Online Reservations™ can provide you with a diverse amount of choices of the best luxury stays in Eastern Panama.


People Also Ask

Online Reservation in Eastern Panama

Recently Booked Hotels, Resorts, or Rentals in Eastern Panama